AFC Summer 2013 meeting

AFC Summer 2013

Held at University College, Dublin

July 4th-5th 2013

Scientific Programme

Session 1: University College Dublin Symposium and guest speakers

Guest speaker
Prof Patrick Brennan, Colorado State University

Host preference across the Mycobacterium tuberculosis complex
Stephen Gordon, University College Dublin

Wildlife intervention strategies for control of bovine tuberculosis
Eamonn Gormley, School of Veterinary Medicine, UCD, Dublin

Session 2: Trinity College Dublin Symposium and guest speakers

Invited talk: TB vaccine efficacy trials:what can we learn and what’s next?
Helen McShane, University of Oxford

Joe Keane, Trinity College Dublin

Phylogenetic lineages of tuberculosis isolates associate with specific patient demographics in New Zealand
Ronan F O’Toole, Trinity College Dublin

The ancient evolution of tuberculosis as a zoonosis
David E Minnikin, University of Birmingham, Birmingham

Session 3: Offered papers

David McHugh, University College Dublin

Genetic Analyses of a Conserved Virulence Regulon in the Mycobacterium tuberculosis complex
Claire Healey, University College Dublin

The Synthesis and Biological Evaluation of Mycobacterial p-Hydroxybenzoic Acid Derivatives (p-HBADs)
Eoin Sacnlan, Trinity College Dublin

My-D88 adapter like (Mal) is required for effective macrophage responses To Mycobacterium tuberculosis
Cliona Ni Cheallaigh, Trinity College Dublin

Insights into the global metabolic changes in mycobacteria during nitrogen stress
Kerstin Williams, Imperial College London

Session 4: Offered papers

Biofilms and antibiotic tolerance: transcriptomic profiles of Mycobacterium smegmatis biofilms
S.A. Lethbridge, Public Health England, Porton Down, Salisbury

Genome-wide mapping of transcription start sites defines an extensive leaderless transcriptome in Mycobacterium tuberculosis
Teresa Cortes,National Institute for Medical Research, MRC, London

A transposon-mutagenesis library to study mechanisms of drug resistance in Mycobacterium tuberculosis
Joana Fonseca, University College London

Mannan core branching of lipo(arabino)mannan is required for initiation of mycobacterial granuloma formation in vivo
Arun K. Mishra, MRC National Institute of Medical Research, London

Mycobacterium leprae – A genome lost in time
Thomas A. Mendum, University of Surrey

AFC Winter 2013 meeting

AFC Winter 2013

Held at the Royal Free Hospital, London

January 11th 2013

Scientific Programme

Session 1

Human plasma miRNA and snoRNA molecules are significantly downregulated in tuberculosis-infected individuals in response to chemotherapy but HIV-1 co-infection spoils the picture
Isobella Honeyborne, Shirin Bokari, Silvana Christou, Clare Eckold, Alexander Pym, Timothy McHugh. UCL, London

Carbon fixation and a mixed diet for intracellular Mycobacterium tuberculosis
Dany J V Beste, Katharina Nöh, Sebastian Niedenführ, Tom A Mendum, Nathaniel D Hawkins, Jane L Ward, Michael H Beale, Wolfgang Wiechert and Johnjoe McFadden. Faculty of Health and Medical Sciences, Department of Microbial and Cellular Sciences, University of Surrey

Destruction of lung extracellular matrix by MMP-1 is critical in TB pathogenesis
Basim Al shammari, Takayuki Shiomi, Liku Tezera, Brian D Robertson, Jon S Friedland, Jeanine D’Armiento and Paul Elkington. Department of Infectious Diseases and Immunity, Imperial College London

Non-replicating Mycobacterium tuberculosis elicits a reduced pathogenicity profile and corresponding modifications to the cell wall
Bacon J, Alderwick LJ, Allnutt JA, Gabasova E, Watson R, Hatch KA, Clark SA, Marriott A, Rayner E, Tolley H, Pearson G, Hall G, Besra GS, Wernisch L, Williams A, Marsh PD. Health Protection Agency, Porton Down, Salisbury

Analysis of host gene induction following MVA85A
M. Matsumiya, Z. Lang, J. Meyer, S. Harris, A. Pathan, R. Rowland, A. Minassian, H. Fletcher, H. McShane. The Jenner Institute, University of Oxford

Session 2

MTS2048 a small RNA with a secret
Joanna Houghton, Olga Schubert, Douglas Young and Kristine Arnvig. Division of Mycobacterial Research, MRC National Institute for Medical Research, Mill Hill, London

Structure of M. tuberculosis DprE1, the target of BTZ compounds
Sarah M Batt, Talat Jabeen, Veemal Bhowruth, Peter A Lund, Luke J Alderwick, Klaus Fütterer, Gurdyal S Besra. School of Biosciences, University of Birmingham

Discovery of the anti-tubercular specific activity of ibuprofen and other 2-arylpropanoic acids using the HT-SPOTi whole-cell phenotypic assay
Juan David Guzman, Dimitrios Evangelopoulos, Antima Gupta, Kristian Birchall, Solomon Mwaigwisya, Simon Gibbons, Barbara Saxty, John Malkinson, Timothy D. McHugh and Sanjib Bhakta. Mycobacteria Research Laboratory, Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College, London

Selective ESAT6-dependent necrosis of phosphatidylserine externalised neutrophils
Robert J Francis, Rachel E Butler, Graham Stewart. Department of Microbial and Cellular Sciences, Faculty of Health and Medical Sciences, University of Surrey

Ethnic variation in inflammatory profile in tuberculosis
Adrian R. Martineau, Anna K. Coussens, Robert J. Wilkinson, Vladyslav Nikolayevskyy, Francis A. Drobniewski, Paul T. Elkington, Graham H. Bothamley, Robert N. Davidson, Christopher J. Griffiths. Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Blizard Institute, London E1 2AB, Division of Mycobacterial Research, MRC National Institute for Medical Research, London