Author: neilstoker

Senior RA in Molecular Microbiology/Biochemistry Full Time (18 months) Deadline 14th Sept 2015

Senior Research Assistant in Molecular Microbiology/Biochemistry Full Time – Fixed-Term for 18 months

Working in the well-appointed laboratories of the Department of Applied Sciences at our Newcastle city campus, you will conduct research that is expected to drive innovation in drug and vaccine development.  Specifically, you will investigate lipid modification of proteins in the outer membrane of mycolic acid-containing bacteria, predominantly the equine pathogen Rhodococcus (Prescottella) equi. We expect to demonstrate that protein lipid modifications are relevant to the virulence of this pathogen and its close relatives, including important human pathogens.

You will have a PhD in a relevant biological discipline with experience in bioinformatics, molecular cloning, protein purification and biochemical assays.  Some knowledge of proteomics and/or assay development is also desirable.  We wish to appoint an excellent communicator with well-developed research and analytical skills who has the ability to work as an integral and co-operative member of our research group.

For an informal discussion about the post, please contact Dr Lynn Dover on (0191) 2273975 or via lynn.dover [AT]

Closing Date for applications: 12 noon on 14th September 2015

Selection Date: 5th October 2015

AFC Summer 2015 meeting registration

The Acid Fast Club Summer Meeting 2015

to be held on Friday 3rd July 2015

at The University of Birmingham,  Birmingham B15 2TT

Local Organiser: Luke Alderwick (l.alderwick [AT]

The Summer Meeting will be held at The University of Birmingham July 3rd 2015; for the final programme and directions, see below.

The timeline is short for registration.  Please pay for your booking by PayPal if you can by going to this site, and email the confirmation with the booking form to Luke Alderwick no later than Friday 5th June. If you do not use PayPal please send a cheque payable to the Acid Fast Club along with your booking form to Luke

AFC Programme Summer 2015_final


AFC Winter 2015 meeting

AFC Winter 2015

Held at The National Institute for Medical Research, London

January 9th 2014

Scientific Programme

Session 1 (History of AFC and Offered papers)

A brief history of the Acid Fast Club
Ann Rawkins. Public Health England, Porton Down

Toll-like receptor and inflammasome mediated response in HIV-tuberculosis-associated immune reconstitution inflammatory syndrome
Rachel PJ Lai, Graeme Meintjes, Katalin A Wilkinson, Christine M Graham, Suzaan Marais, Helen Van der Plas, Armin Deffur, Charlotte Schutz, Chloe Bloom, Indira Munagala, Esperanza Anguiano, Rene Goliath, Gary Maartens, Jacques Banchereau, Damien Chaussabel, Anne O’Garra & Robert J Wilkinson. Division of Mycobacterial Research, MRC National Institute for Medical Research

Role of Rab20 during Mycobacterium tuberculosis phagosome trafficking
Laura Schnettger, Gang Pei & Maximiliano G. Gutierrez
Mycobacterial Research, MRC National Institute for Medical Research

M. tuberculosis dysregulates vitamin D metabolism
Karolina D Witt, Zhican Wang, Kashaf Junaid, Anna K Coussens, David A Jolliffe, Robert J Wilkinson, Kenneth E Thummel & Adrian R Martineau. Queen Mary University of London.

Investigating the role of hepcidin and iron metabolism in a murine model of Mycobacterium tuberculosis infection
Rachel Harrington-Kandt, Elena Stylianou, Hal Drakesmith & Helen McShane. Jenner Institute, University of Oxford

The role of nitric oxide in the production of Rpf-dependent mycobacteria
Sarah Glenn, Obolbek Turapov, Vadim Marakov, Bavesh Kana, Peter Andrew & Galina Mukamolova. Department of Infection, Immunity and Inflammation, University of Leicester

Session 2: Offered papers and Douglas Young

Primary human airway epithelial cells are early responders to tuberculosis infection
Ann-Katrin Reuschl, M Edwards, D Connell, N Siddiqui, H Lambie, S Bremang, OM Kon, R Shattock & A Lalvani. Tuberculosis Research Centre, NHLI, Imperial College London

Helminth induced CD4+FoxP3+ T cells are associated with an impaired immune response to Mycobacterium tuberculosis
Frederic Toulza, Lilian Tsang, Michael Brown & Hazel Dockrell; London School of Hygiene and Tropical Medicine

Phenotypic resistance in mycobacteria is associated with the presence of lipid bodies not age of cells
Robert Hammond, Han Xiao, Katarina Orvacova & Stephen Gillespie. School of Medicine, University of St.Andrews

Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick type C disease cellular pathway
Paul Fineran, E. Lloyd-Evans, N. A. Lack, N. Platt, L. C. Davis, A. J. Morgan, R. Tatoturi, D. Kelly, S. Clark, A. Williams, I. Williams, W. Tynan, N. Al Eisa, A. Galione, D. Ory, D. Russell, M. Brenner, E. Sim & F. M. Platt. Department of Pharmacology, University of Oxford

Molecular profiling of the tuberculin skin test reveals diverse effects of HIV-1 infection in active tuberculosis
Lucy CK Bell, Gabriele Pollara, Mellissa Pascoe, Gillian Tomlinson, Rannakoe J. Lehloenya, Richard Meldau, Paul Elkington, Robert Miller, Alan Ramsey, Benjamin Chain, Keertan Dheda & Mahdad Noursadeghi

Mill Hill and the Acid Fast Club
Douglas Young. NIMR/Crick

Programme details (Word file)

An introduction to infectious disease genomics – an IDRN event

An introduction to infectious disease genomics – an IDRN event
Thursday 18 June 2015
Royal Society, Carlton House Terrace, central London

The day will be pitched at ‘beginner level’ to give an idea of the topics and concepts covered in this area. As infectious disease genomics becomes rapidly more mainstream and relevant to clinical practice and translational research, it is increasingly important for academics, clinical staff and public health professionals to understand what genomics can and cannot do, what its data requirements are, and how to critically appraise the outputs. This event will provide a taster of:

  • what infectious disease genomics in 2015 is all about
  • how it does and will impact on practice
  • the ethical concerns behind it
  • how the generated data can best be managed and who will own it?

There will also be case studies from researchers who are active in genomics from the point of view of bacteriology, virology and mycology. Speakers will be Michael Head (IDRN and UCL), David Cleary (Southampton), Judy Breuer (UCL), Nick Loman (Birmingham), Dan Frampton (UCL), Johanna Rhodes (Imperial), Phillip Ashton (Public Health England), Tom Fowler (Genomics England), and Claudio Koser (Cambridge). The speakers have internationally-recognised expertise and are members of national and international expert groups.

See for more information and online registration.

AFC Summer 2015 meeting

Friday 3rd July 2015

at the University of Birmingham, Birmingham B15 2TT

(Local Organiser: Luke Alderwick)

Call for abstracts

Offered papers should be sent on this form to the meetings secretary, Tine Arnvig (k.arnvig <AT> no later than Friday 24th April.  All papers should include the title, affiliation of each author and a short summary (no more than 100 words). Papers cannot be considered after the club’s committee meeting.

Nominations for new members may also be sent to Tine Arnvig. Please provide the name of the nominating and seconding members and the full contact details of the proposed member no later than Friday 24th April.

Remember that if you nominate a new member you should expect to attend the meeting!

Senior Scientist position in Jena, deadline 02 March 2015

The Institute of Molecular Pathogenesis (IMP) at the Jena site of the FLI invites applications for a fulltime position at senior scientist level, corresponding to

Scientific Councilor (pay grade A 13 BBesO)

Wissenschaftliche Rätin/ Wissenschaftlicher Rat (Besoldungsgruppe A 13 BBesO),

to conduct research on the molecular pathogenesis of members of the Mycobacterium tuberculosis complex in livestock and wildlife ungulates

Further details of this position, including qualification requirements, are described in Job Announcement 04/15 posted on our website:

Applicants should submit an application written in German or English including a description of research interests and the motivation to apply, official transcripts, a detailed CV highlighting education, relevant experience, qualifications, grant and contract activities and publications to Fachbereich Personal, Postfach 1318, 17466 Greifswald-Insel Riems. Electronic applications may be submitted as a single PDF document to marked with reference number ‘Stelle 04/15’. Applications must be received by the closing date of March 02, 2015.

Download pdf

AFC Winter 2015 meeting registration

The Acid Fast Club Winter Meeting 2015 & AGM

to be held on Friday 9th January 2015

at The National Institute for Medical Research, Mill Hill, London NW7 1AA

Local Organisers: Teresa Cortes & Douglas Young (tcortes [AT] and dyoung [AT]

Programme for the Winter Meeting and AGM which will be held at NIMR, Mill Hill on January 9th 2015. This will be the last of many memorable Acid Fast Club meetings at Mill Hill and I hope that as many of you as possible will be able to attend. For those who could not attend the anniversary meeting in Berlin, included in the winter programme is a fascinating perambulation through the history of the Club by Ann Rawkins.

The timeline is short for registration. Please register by emailing your forms to Teresa Cortes by midnight December 12th and also pay any registration fees for your guests and payment for the post-talks buffet reception via the PayPal link here (cheques sent to Teresa only if you cannot negotiate PayPal)

4 yr Research Associate in Mucosal Vaccinations (Deadline 07 December 2014)

We seek to appoint a postdoctoral Research Associate to a project aimed at investigating the mechanisms of mucosal vaccination against tuberculosis in experimental models.

The purpose is to evaluate cellular immune mechanisms and protection, following mucosal delivery of CD8 T cell stimulatory epitope subunit vaccine constructs. This will involve analysis of T cell responses and protection of HLA-transgenic and humanised mice, testing of blood samples from previously sensitized macaques and study of antigen presentation using human cell lines.

The post, attached to Professor J. Ivanyi ( will be based in the Mucosal and Salivary Biology Division, at the Guy’s Hospital Campus of King’s College London. We are looking for an individually motivated scientist to interact creatively with a number of collaborating teams within and outside Guy’s-KCL. PhD qualified candidates should have knowledge and experience (i.e. publications) in the subject and methodologies of cellular and molecular immunology with reference to microbial infections in animal experimental models.

Closing date: 07 December 2014

  • Reference: THW/14/059639/415
  • Salary Details: £32,277 per annum
  • Allowances: £2,323 London Weighting
  • Contract Type: Temporary/Fixed term for a period of four years
  • Contract Term: Full time
  • Equality of opportunity is College policy.

To obtain further information, Job description and Application form please register at one of the following websites:

5 year RA / Postdoc positions at NIMR deadlines 10 / 30 Sept 2014

National Institute of Medical Research: Division of Mycobacterial Research

Research Technician

We are offering one 5-year Research Assistant position, to support work on mycobacterial metabolism and nutrient acquisition, in NIMR’s Division of Mycobacterial Research.  Application deadline 10 September 2014.

If interested, please visit:

Postdoctoral Scientist

 Ref: IRC156893

We are offering two 5-year Postdoctoral Scientist positions, which are training and development positions for post-doctoral scientists, in NIMR’s Division of Mycobacterial Research. Application deadline 30 September 2014.

If interested, please visit: