AFC Winter 2013 meeting

AFC Winter 2013

Held at the Royal Free Hospital, London

January 11th 2013

Scientific Programme

Session 1

Human plasma miRNA and snoRNA molecules are significantly downregulated in tuberculosis-infected individuals in response to chemotherapy but HIV-1 co-infection spoils the picture
Isobella Honeyborne, Shirin Bokari, Silvana Christou, Clare Eckold, Alexander Pym, Timothy McHugh. UCL, London

Carbon fixation and a mixed diet for intracellular Mycobacterium tuberculosis
Dany J V Beste, Katharina Nöh, Sebastian Niedenführ, Tom A Mendum, Nathaniel D Hawkins, Jane L Ward, Michael H Beale, Wolfgang Wiechert and Johnjoe McFadden. Faculty of Health and Medical Sciences, Department of Microbial and Cellular Sciences, University of Surrey

Destruction of lung extracellular matrix by MMP-1 is critical in TB pathogenesis
Basim Al shammari, Takayuki Shiomi, Liku Tezera, Brian D Robertson, Jon S Friedland, Jeanine D’Armiento and Paul Elkington. Department of Infectious Diseases and Immunity, Imperial College London

Non-replicating Mycobacterium tuberculosis elicits a reduced pathogenicity profile and corresponding modifications to the cell wall
Bacon J, Alderwick LJ, Allnutt JA, Gabasova E, Watson R, Hatch KA, Clark SA, Marriott A, Rayner E, Tolley H, Pearson G, Hall G, Besra GS, Wernisch L, Williams A, Marsh PD. Health Protection Agency, Porton Down, Salisbury

Analysis of host gene induction following MVA85A
M. Matsumiya, Z. Lang, J. Meyer, S. Harris, A. Pathan, R. Rowland, A. Minassian, H. Fletcher, H. McShane. The Jenner Institute, University of Oxford

Session 2

MTS2048 a small RNA with a secret
Joanna Houghton, Olga Schubert, Douglas Young and Kristine Arnvig. Division of Mycobacterial Research, MRC National Institute for Medical Research, Mill Hill, London

Structure of M. tuberculosis DprE1, the target of BTZ compounds
Sarah M Batt, Talat Jabeen, Veemal Bhowruth, Peter A Lund, Luke J Alderwick, Klaus Fütterer, Gurdyal S Besra. School of Biosciences, University of Birmingham

Discovery of the anti-tubercular specific activity of ibuprofen and other 2-arylpropanoic acids using the HT-SPOTi whole-cell phenotypic assay
Juan David Guzman, Dimitrios Evangelopoulos, Antima Gupta, Kristian Birchall, Solomon Mwaigwisya, Simon Gibbons, Barbara Saxty, John Malkinson, Timothy D. McHugh and Sanjib Bhakta. Mycobacteria Research Laboratory, Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College, London

Selective ESAT6-dependent necrosis of phosphatidylserine externalised neutrophils
Robert J Francis, Rachel E Butler, Graham Stewart. Department of Microbial and Cellular Sciences, Faculty of Health and Medical Sciences, University of Surrey

Ethnic variation in inflammatory profile in tuberculosis
Adrian R. Martineau, Anna K. Coussens, Robert J. Wilkinson, Vladyslav Nikolayevskyy, Francis A. Drobniewski, Paul T. Elkington, Graham H. Bothamley, Robert N. Davidson, Christopher J. Griffiths. Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Blizard Institute, London E1 2AB, Division of Mycobacterial Research, MRC National Institute for Medical Research, London