AFC Summer 2009 meeting

AFC Summer 2009

Held at the Moredun Research Institute, Edinburgh

July 2nd-3rd 2009

Scientific Programme

Session 1: Research at the Moredun

Johne’s disease: an overview of research at Moredun
Karen Stevenson, Valerie Hughes, Craig A Watkins, Linda May, Susan Denham, Ian Heron and Joyce McLuckie:

Corynebacterium pseudotuberculosis – from genome to prevention
Florence E Pethick, Alex Lainson, Michael C Fontaine

Session 2

Phenotype microarray platform: Potential and pitfalls for use with pathogenic mycobacteria
Bhagwati Uphadyay and Paul R Wheeler. Veterinary Laboratories Agency, Weybridge

Fast growing, non-infectious and intra-cellularly surviving drug-resistant Mycobacterium aurum: A model for high-throughput anti-TB drug screening
Antima Gupta, Sanjib Bhakta, Subir Kundu, Manish Gupta, Brahm S. Srivastava, and Ranjana Srivastava. Central Drug Research Institute, India & Birkbeck College, University of London.

Kinetic Profiling of Immune responses to PE/PPE proteins in M. bovis-infected Cattle
H.M. Vordermeier, R.G. Hewinson, D.B. Young, S.L. Sampson. VLA Weybridge& Imperial College London

Session 3

Life and death in the mycobacterial phagosome
Rachel Shrimpton, Priscille Brodin, Olivier Neyrolles, Graham Stewart. Division of Microbial Sciences, University of Surrey, UK

Identification of 2-aminothiazole—4-carboxylate derivatives active against Mycobacterium tuberculosis H37Rv and the ketoacyl-ACP synthase mtFabH
Qosay Al-Balas, Nahoum G. Anthony, Bilal Al-Jaidi, Amani Alnimir, Grainne Abbott, Alistair K. Brown, Rebecca C. Taylor, Gurdyal. S. Besra, Timothy D. McHugh, Stephen H. Gillespie, Blair F. Johnston, Simon P. Mackay, Geoffrey D. Coxon. University of Strathclyde, Glasgow.

BCG: surrogate for a human TB challenge?
Minassian, A, Tchilian, E, Poulton, I, Fletcher, H, Andrews, L,   Poyntz, H, Ronan, E,   Hill, A, & McShane, H. The Jenner Institute, Oxford University

Acute and persistent Mycobacterium tuberculosis infections depend on the thiol peroxidase Tpx
Yanmin Hu and Anthony R. M. Coates. St George’s University of London.


Genes and proteins of the nat/hsaD gene cluster and their role in cholesterol metabolism
Nathan Lack, Dimitrios Evangelopoulos, Sanjib Bhakta, Lindsay Eltis, Areej Abuhammad, Elizabeth Fullam, Edward Lowe and Edith Sim. University of Oxford.

Session 4

Structure and functional characterisation of Mycobacterium tuberculosis diaminopimelic acid epimerase (MtDapF)
Veeraraghavan Usha, Lynn G. Dover, Klaus Fütterer, David L. Roper, Adrian J. Lloyd and Gurdyal S. Besra. University of Birmingham

The helicase UvrD2 is essential in Mycobacterium tuberculosis
Alan Williams, Burkhard Springer, Erik C. Böttger, and Elaine O. Davis. NIMR, Mill Hill, London

Dissection of regenerating T cell responses against tuberculosis in HIV infected adults with latent tuberculosis
Katalin A. Wilkinson, Ronnett Seldon, Graeme Meintjes, Molebogeng X. Rangaka, Willem A. Hanekom, Gary Maartens, Robert J. Wilkinson. University of Cape Town, South Africa

Live cell imaging to study growth and cell division in mycobacteria
Graham Joyce, Kerstin J. Williams, and Brian D. Robertson. Imperial College London